Impact of a Muscarinic Acetylcholine

Question: What is the impact of a muscarinic acetylcholine antagonist named scopolamine pre-training intra-MS and intra-CA1 administration as well as NMDA receptor agents administration and their co-administration on the development of memory in hippocampus and septum connections? Answer: In this article, scientists has tried to analyse the impact of two drugs and their combined interaction on the brain regions where the presence of drugs is likely considered to initiate effect on memory acquisition in that region. By using animal models Two drugs scopolamine (acetylcholine agents) and NMDA (receptor agents) are involved in the arena of this study where their impact on hippocampus and septum connective region is been analysed by forming different experiment designs. Firstly, these drugs are administrated separately on experiment models and their impact is studied further the same drugs are co-administrated to gather a more detailed understanding of their impact in this brain region. The research question is properly articulated because it directly indicated the aim of research focussing on the study of drug administration and co-administration impact on the brain. In medical science, analysing the impact of medications in the different form on the human body is a very important requirement to understand drug mechanism, side effects, effects and essentiality. This study focuses on two particular drugs working in the living body. The hypothesis in the research is not mentioned in a separate section but it is clearly been stated in the introduction that the research involves a study on analysing that drugs initiate or do not work on acquisition memory pathway. However, there are no specific null hypothesis and alternative hypothesis mentioned in this study. Method This research is an applied research that involves a systematic experimental inquiry on the basis of practically designed and performed science experiments. As the individual purpose of applied research is to develop a practical answer of inquiry by getting experimental and logical methods, ideas, programs and projects. Similarly, this research also focuses on designing logical experiments for getting a practically quantified answer to their research question. This research is a quantitative research because the study involves practically designed eight experiments that were performed on the animal models (Adult Wistar rat males) to get the observations related to experiment design and further the observations and numerical data was tested using statistical analysis. As per studies, quantitative research is a process that is based on developing statistical, logical, computational or mathematical findings for the research observations and data. Therefore, this research is purely a quantitative research. Yes, time was taken into account while performing the research experiments related to the injection of drugs in the animal model. The time taken into administration was 5 minutes where the first drug injection was done 5 minutes prior to training and the second drug was administrated just 5 minutes after the first drug injection in experiment model. Therefore, time was an important factor in this particular research and was accounted in experiment design. This is a descriptive research because the research involves observational method, which is one kind of descriptive research method. The descriptive research involves the purpose of describing research situation on the basis of observational methods, case study methods or survey methods. The observational methods of descriptive research involve both natural and laboratory observations. Therefore, as this research focuses on studying animal behaviour by developing laboratory observation indicating that it is a descriptive research. Rating This article can get a rating of 8 out of 10 in terms of its logic and experiment results that are obtained in the research. The research question developed in the study is very clear and the eight experiments designed in the research justify the research question to get the best possible outcomes. But, the reason of giving a rating 8 but not 10 is the clarity of research paper because the article language is very complicated especially to be understood as per academic viewpoint, the terminologies used are very complicated that can be presented using easy languages. Further, the statistical findings are confusing with the only graphical presentation but no tables are used in the article to represent the statistical data that gives a complicated appearance to the research. However, the logic and research design are up to the mark in this research paper.